Strategies for spatiotemporal regeneration

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Strategies for spatiotemporal regeneration

Contact us Fibrogelnet project High incidence of degenerative skeletal tissue disorders in a progressively aging human population make tissue engineering of cartilage and bone a focus of extensive research.

Tissue and Organ Regeneration | Advances in Micro- and Nanotechnology | Taylor & Francis Group

Bone and joint disorders are the most common disease in Europe: This project is designed to supplement the previous EuroNanoMed project aimed to develop an innovative strategy for targeting bone and cartilage regeneration.

More specifically the proposal seeks to set up an international multidisciplinary team of young scientists and engineers representing both academia and industry partners that will strongly contribute to the design of a novel type of implant, which can strongly promote tissue regeneration combining high performance materials, advanced nanotechnology and living cells.

Network for Development of Soft Nanofibrous Construct for Cellular Therapy of Degenerative Skeletal Disorders The major objective of this project is to bring together the expertise of academia and industry partners for the development of an innovative complementary strategy for targeting bone and cartilage regeneration.

They will be involved in the design of an advanced tissue engineering construct comprising of bioinspired gel with unique biomechanical properties containing oriented nanofibres and bioactive molecules resembling the natural spatiotemporal cues of the extracellular matrix.

It is further combined with human mesenchymal stem cells hMSC differentiating into osteogenic or chondrogenic lineages. This challenging approach requires collaboration of researchers from different disciplines such as materials science, chemistry, nanoengineering and cell biology.

Fibrogelnet project

The involvement of both academia and industrial partners will assure the bidirectional transfer of knowledge and shall result in the creation of commercial product s expecting medical application.

The proposed multidisciplinary approach aims to gain radical innovation in the strategy for treatment of the skeletal disorders with a strong impact in the long term for a variety of fields such as nanobioengineering and regenerative medicine. Built using WordPress and Reiki Theme.This paper reviews the current approaches to using 3D printed structures to deliver bioactive factors (e.g., cells and biomolecules) for tissue repair and discuss the benefits and critical points of potential scaffold materials and delivery strategies, particularly approaches that entail spatiotemporal variation in delivery.

regeneration strategies with spatiotemporal presentation of multiple biological signals may provide a novel treatment foundation for the repair and regeneration of complex multiphase structures, such as the osteochondral junction. Recently, periodontal regeneration strategies have been developed to facilitate spatiotemporal morphogenesis and the organization of ļ¬brous connective tissue and mineralized structures in .

The field of regenerative medicine encompasses numerous strategies, including the use of materials and de novo generated cells, as well as various combinations thereof, to take the place of missing tissue, effectively replacing it both structurally and functionally, or to contribute to tissue healing.

In this review, we summarize state-of-the-art knowledge regarding applications and challenges of MSC-mediated bone healing, further offering principles and effective strategies to optimize MSC-based bone regeneration in aging and diseases.

Strategies for spatiotemporal regeneration

The Center for Regenerative Medicine is developing new tools to effectively control the process of neural injury and degeneration and to create a microenvironment that enhances the capacity for innate repair and the efficacy of other regeneration strategies, including neural cell replacement and neurorehabilitation.

Strategies for Human Adipose Tissue Repair and Regeneration